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Table 4 P-values and r-squared values (in parentheses) obtained from multi factorial ANOVA models of the effect of sex, ELS, and combined 5-HTTLPR rs25531 genotype grouped according to Wendland et al. [ 23 ] on SLC6A4 methylation

From: New-born females show higher stress- and genotype-independent methylation of SLC6A4 than males

  CpG site
Predictor in model 1 2 3 4 Mean across sites
Sex 4.5e-08 (0.300) 1.4e-09 (0.367) 9.7e-08 (0.286) 3.9e-08 (0.310) 6.3e-10 (0.371)
ELS 0.82 (0.000) 0.68 (0.004) 0.86 (0.001) 0.87 (0.000) 0.98 (0.001)
Genotype_HL 0.11 (0.074) 0.83 (0.017) 0.66 (0.015) 0.68 (0.030) 0.76 (0.027)
Sex x ELS 0.69 (0.001) 0.43 (0.005) 0.66 (0.003) 0.56 (0.003) 0.69 (0.001)
Sex x Genotype_HL 0.67 (0.006) 0.65 (0.007) 0.67 (0.006) 0.81 (0.004) 0.71 (0.005)
ELS x Genotype_HL 0.81 (0.003) 0.58 (0.009) 0.77 (0.004) 0.84 (0.004) 0.74 (0.005)
  1. Significant p-values are shown in bold. ELS = early life stress; Genotype_HL = 5-HTTLPR rs25531 multi marker genotype, _HL = _HighLow genotype grouping according to Wendland et al. [23].