Table 4 P-values and r-squared values (in parentheses) obtained from multi factorial ANOVA models of the effect of sex, ELS, and combined 5-HTTLPR rs25531 genotype grouped according to Wendland et al. [ 23 ] on SLC6A4 methylation
From: New-born females show higher stress- and genotype-independent methylation of SLC6A4 than males
| Â | CpG site | ||||
|---|---|---|---|---|---|
Predictor in model | 1 | 2 | 3 | 4 | Mean across sites |
Sex | 4.5e-08 (0.300) | 1.4e-09 (0.367) | 9.7e-08 (0.286) | 3.9e-08 (0.310) | 6.3e-10 (0.371) |
ELS | 0.82 (0.000) | 0.68 (0.004) | 0.86 (0.001) | 0.87 (0.000) | 0.98 (0.001) |
Genotype_HL | 0.11 (0.074) | 0.83 (0.017) | 0.66 (0.015) | 0.68 (0.030) | 0.76 (0.027) |
Sex x ELS | 0.69 (0.001) | 0.43 (0.005) | 0.66 (0.003) | 0.56 (0.003) | 0.69 (0.001) |
Sex x Genotype_HL | 0.67 (0.006) | 0.65 (0.007) | 0.67 (0.006) | 0.81 (0.004) | 0.71 (0.005) |
ELS x Genotype_HL | 0.81 (0.003) | 0.58 (0.009) | 0.77 (0.004) | 0.84 (0.004) | 0.74 (0.005) |