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Table 3 P-values and r-squared values (in parentheses) obtained from multi factorial ANOVA models of the effect of sex, ELS, and 5-HTTLPR genotype on SLC6A4 methylation

From: New-born females show higher stress- and genotype-independent methylation of SLC6A4 than males

  CpG site
Predictor in model 1 2 3 4 Mean across sites
Sex 3.9e-08 (0.302) 2.3e-09 (0.361) 1.2e-07 (0.288) 3.7e-08 (0.311) 7.5e-10 (0.371)
ELS 0.94 (0.000) 0.67 (0.004) 0.92 (0.001) 0.96 (0.000) 0.94 (0.001)
Genotype 0.12 (0.070) 0.47 (0.028) 0.95 (0.005) 0.72 (0.027) 0.75 (0.025)
Sex x ELS 0.76 (0.001) 0.33 (0.006) 0.78 (0.003) 0.56 (0.003) 0.63 (0.002)
Sex x Genotype 0.50 (0.011) 0.61 (0.008) 0.73 (0.004) 0.51 (0.011) 0.57 (0.008)
ELS x Genotype 0.79 (0.003) 0.41 (0.013) 0.44 (0.012) 0.74 (0.005) 0.52 (0.009)
  1. Significant p-values are shown in bold. ELS = early life stress; 5-HTTLPR genotype = SLC6A4-linked polymorphic region genotype.